Biomathematics: Personalized Optimal Regulation of Circadian Rhythms and Related Processes

Funding Organization: 
Principal Investigator: 
Co-PIs: 

John Wen

Dates: 
April 1, 2022 to March 31, 2025
Amount: 
$503,935
Grant Status: 
Current
Abstract: 

The goal of the project is to develop personalized optimal regulation strategies for circadian rhythms and the related processes, including in the context of detecting and mitigating the impacts of mild traumatic brain injury (mTBI). A large part of our approach will be data-driven, leveraging the availability of biometric signals from the subjects. To reach this goal, our research program is organized towards the following objectives:

1. Evaluating and enhancing robustness of optimal regulation of circadian rhythms and the related processes under model uncertainties.

2. Developing algorithms for learning and adaptation in optimal regulation of circadian rhythms and related processes.

3. Developing algorithms for detecting and mitigating the impacts of mild Traumatic Brain Injuries (TBI) on circadian rhythms and related processes.